Dataset
PGx Atlas
Pre-computed peptide candidates for 50 clinically validated pharmacogenomic variants
What’s included
- 50 variants from CPIC Level A, FDA-labeled biomarkers, and PharmGKB VIP genes
- ClinVar annotation and clinical significance for every variant
- UniProt protein targets mapped per variant
- Ranked peptide candidates with full 10-dimensional pharmacogenomic scores
- ESMFold-predicted 3D structures for each candidate peptide
- Fmoc-SPPS synthesis protocols ready for bench validation
JSON
Structured, machine-readable. Ideal for pipeline integration.
CSV
Flat tabular format. Import directly into R, Python, or Excel.
HTML
Human-readable reports with embedded 3D viewers and protocol details.
Sample variants
10 of 50 variants included in the atlas
| rsID | Gene | Variant | Clinical Relevance | Tier |
|---|---|---|---|---|
| rs1801133 | MTHFR | C677T | Folate metabolism | A |
| rs429358 | APOE | ε4 | Alzheimer’s risk | B |
| rs4244285 | CYP2C19 | *2 | Clopidogrel response | A |
| rs1799853 | CYP2C9 | *2 | Warfarin dosing | A |
| rs9923231 | VKORC1 | -1639G>A | Warfarin sensitivity | A |
| rs3745274 | CYP2B6 | *6 | Efavirenz metabolism | A |
| rs1065852 | CYP2D6 | *10 | Codeine metabolism | A |
| rs1800460 | TPMT | *3C | Thiopurine toxicity | A |
| rs4149056 | SLCO1B1 | *5 | Statin myopathy | A |
| rs1799971 | OPRM1 | A118G | Opioid response | B |
Tier A = CPIC Level A evidence. Tier B = FDA-labeled or PharmGKB VIP.
Licensing
Use cases
Drug discovery pipeline enrichment
Inject pre-scored peptide candidates into your screening workflow. Skip months of variant annotation and peptide generation.
Academic pharmacogenomics research
Cite curated PGx data in publications and grant applications. Ready-made datasets for cohort studies.
CRO screening panel design
Build client-facing panels from validated variant-peptide pairs. Each entry includes synthesis protocols.
Clinical decision support prototyping
Prototype CDS tools with real pharmacogenomic data. 10D scores map directly to clinical relevance tiers.
How scores are computed
Each peptide candidate is scored across 10 pharmacogenomic dimensions: binding affinity, Grant 12D structural projection, structural stability, clinical relevance, protease resistance, ADMET properties, permeability, aggregation propensity, novelty, and predicted half-life. Read the full methodology
Need a custom variant panel?
Submit your own rsID lists, gene panels, or patient cohort data. We generate the atlas for your specific research needs.