SNP Database
Pharmacogenomic variants relevant to therapeutic peptide design. Each SNP page includes molecular mechanism, peptide therapeutic relevance, gene and condition links, and direct PepFold analysis.
APOE — APOE4 (Cys112Arg) · Alzheimer's disease
APOE — APOE2 (Arg158Cys) · Hyperlipoproteinemia type III
MTHFR — C677T (Ala222Val) · Hyperhomocysteinemia
CYP2D6 — CYP2D6*4 (splicing defect) · Poor drug metabolism
VKORC1 — -1639G>A (promoter) · Warfarin sensitivity
TCF7L2 — Intron 4 (G>T) · Type 2 diabetes
TCF7L2 — Intron 3 (C>T) · Type 2 diabetes
MTHFR — A1298C (Glu429Ala) · Reduced folate metabolism
CYP2C19 — CYP2C19*2 (splicing defect) · Clopidogrel resistance
CYP2C19 — CYP2C19*17 (-806C>T) · Ultra-rapid drug metabolism
CYP2C9 — CYP2C9*2 (Arg144Cys) · Warfarin sensitivity
CYP2C9 — CYP2C9*3 (Ile359Leu) · Warfarin sensitivity
COMT — Val158Met · Pain sensitivity and psychiatric disorders
MC1R — Arg151Cys · Melanoma risk and anesthesia response
AGTR1 — A1166C · Hypertension
AGT — Met235Thr · Hypertension
HBB — Glu6Val (Sickle cell) · Sickle cell disease
BRCA1 — 185delAG (frameshift) · Hereditary breast and ovarian cancer
ANKK1/DRD2 — Taq1A (Glu713Lys) · Addiction susceptibility
OPRM1 — A118G (Asn40Asp) · Opioid response variation
Analyze any rsID with PepFold
PepFold accepts 1-20 rsIDs and generates ranked peptide candidates with 3D structures and synthesis protocols.