Gene Database

Pharmacogenomic genes relevant to therapeutic peptide design. Each profile includes gene function, key variants, peptide therapeutic approaches, and links to associated conditions.

APOEChr 19q13.32

Apolipoprotein E

Alzheimer's disease · Cardiovascular disease · Hyperlipoproteinemia type III

MTHFRChr 1p36.22

Methylenetetrahydrofolate Reductase

Hyperhomocysteinemia · Neural tube defects · Cardiovascular disease

CYP2D6Chr 22q13.2

Cytochrome P450 2D6

Poor drug metabolism · Ultra-rapid metabolism · Adverse drug reactions

CYP2C19Chr 10q23.33

Cytochrome P450 2C19

Clopidogrel resistance · PPI dose variability · Antidepressant response

CYP2C9Chr 10q23.33

Cytochrome P450 2C9

Warfarin sensitivity · NSAID adverse effects · Sulfonylurea hypoglycemia

VKORC1Chr 16p11.2

Vitamin K Epoxide Reductase Complex Subunit 1

Warfarin sensitivity · Vitamin K-dependent coagulation disorders

TCF7L2Chr 10q25.2

Transcription Factor 7-Like 2

Type 2 diabetes · Impaired glucose tolerance · Beta-cell dysfunction

COMTChr 22q11.21

Catechol-O-Methyltransferase

Pain sensitivity · Psychiatric disorders · Opioid response variation

OPRM1Chr 6q25.2

Mu-Opioid Receptor 1

Opioid response variation · Pain sensitivity · Addiction susceptibility

HBBChr 11p15.4

Hemoglobin Subunit Beta

Sickle cell disease · Beta-thalassemia · Hemoglobin disorders

BRCA1Chr 17q21.31

BRCA1 DNA Repair Associated

Hereditary breast cancer · Ovarian cancer · Prostate cancer

MC1RChr 16q24.3

Melanocortin 1 Receptor

Melanoma risk · Anesthesia response variation · UV sensitivity