What genetic variants are associated with Warfarin Sensitivity?

Key pharmacogenomic variants: rs9923231 in VKORC1, rs1799853 in CYP2C9, rs1057910 in CYP2C9. Genes involved: VKORC1, CYP2C9, CYP4F2.

How can PepFold help with Warfarin Sensitivity research?

PepFold accepts the rsIDs associated with Warfarin Sensitivity (rs9923231, rs1799853, rs1057910) and generates computational peptide candidates targeting the affected proteins. Each candidate comes with predicted 3D structures, 10-dimension scoring, and Fmoc-SPPS synthesis protocols.

Condition Database

Warfarin Sensitivity

Prevalence: ~2 million US patients on warfarin, ~30% experience dosing complications

Genetic variation in VKORC1 and CYP2C9 determines warfarin dose requirements. FDA recommends pharmacogenomic testing, and genotype-guided dosing reduces bleeding events by 30%. It is the most established pharmacogenomic application in clinical practice.

Peptide Therapeutics

Peptide anticoagulants targeting thrombin (bivalirudin class), Factor Xa inhibitor peptides, and VKORC1-selective peptide modulators offer genotype-independent alternatives to warfarin.

Current Treatments

Warfarin (with pharmacogenomic dosing), DOACs (rivaroxaban, apixaban, dabigatran), bivalirudin (peptide-based, IV only).

Key Genetic Variants

rs9923231~45% Caucasians, >90% East Asians

VKORC1 — -1639G>A (promoter)

rs1799853~12% Caucasians

CYP2C9 — CYP2C9*2 (Arg144Cys)

rs1057910~7% Caucasians

CYP2C9 — CYP2C9*3 (Ile359Leu)

Associated Genes

VKORC1Vitamin K Epoxide Reductase Complex Subunit 1

Direct pharmacological target of warfarin. Recycles vitamin K, essential for gamma-carboxylation of clotting factors II, VII, IX, and X.

CYP2C9Cytochrome P450 2C9

Metabolizes ~15% of clinical drugs including warfarin (S-enantiomer), NSAIDs, sulfonylureas, and losartan. CYP2C9 genotype is part of FDA warfarin dosing guidelines.

CYP4F2Profile coming soon

Explore peptide candidates for Warfarin Sensitivity

Submit rs9923231, rs1799853, rs1057910 to PepFold. Full report with 3D structures and synthesis protocols in under 2 minutes.

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