What pharmacogenomic variants are known in APOE?

Key variants in APOE: rs429358 (APOE4 (Cys112Arg)), rs7412 (APOE2 (Arg158Cys)). These variants are associated with Alzheimer's disease, Cardiovascular disease, Hyperlipoproteinemia type III.

Can PepFold design peptides targeting APOE?

Yes. PepFold accepts rsIDs associated with APOE, maps them to the protein structure, and generates peptide candidates. HDL-mimetic peptides (4F, D-4F), APOE-receptor interaction modulators (CS6253), and aggregation inhibitors targeting the lipid-binding domain.

Gene Database

APOE — Apolipoprotein E

Q: What is the APOE gene?

APOE (Apolipoprotein E) is located on chromosome 19q13.32. Lipid transport, cholesterol metabolism, neuronal repair, and amyloid-beta clearance in the brain. APOE is the major genetic risk modulator for late-onset Alzheimer's disease.

Chromosome 19q13.32

Lipid transport, cholesterol metabolism, neuronal repair, and amyloid-beta clearance in the brain. APOE is the major genetic risk modulator for late-onset Alzheimer's disease.

Pharmacogenomic Variants

rs429358Risk factor

APOE4 (Cys112Arg) — Alzheimer's disease

rs7412Protective / Risk factor

APOE2 (Arg158Cys) — Hyperlipoproteinemia type III

Peptide Therapeutic Approaches

HDL-mimetic peptides (4F, D-4F), APOE-receptor interaction modulators (CS6253), and aggregation inhibitors targeting the lipid-binding domain.

Related Therapeutics

Lecanemab (anti-amyloid)AducanumabDonepezil

Associated Conditions

Alzheimer's Disease

The most common neurodegenerative disease, characterized by progressive memory loss, cognitive decline, and amyloid-beta plaque accumulation. Genetic factors account for 60-80% of risk, with APOE4 being the strongest common risk allele.

Cardiovascular Disease (Genetic Risk)

Genetic variants in APOE, AGT, AGTR1, and lipid metabolism genes contribute to cardiovascular risk. Pharmacogenomics guides anticoagulant, antiplatelet, and antihypertensive therapy selection.

Analyze APOE variants with PepFold

Submit rs429358, rs7412 and get ranked peptide candidates in under 2 minutes.

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