What pharmacogenomic variants are known in COMT?

Key variants in COMT: rs4680 (Val158Met). These variants are associated with Pain sensitivity, Psychiatric disorders, Opioid response variation.

Can PepFold design peptides targeting COMT?

Yes. PepFold accepts rsIDs associated with COMT, maps them to the protein structure, and generates peptide candidates. COMT-stabilizing peptides for the Met allele, allosteric modulators for activity normalization, and genotype-informed analgesic peptide design.

Gene Database

COMT — Catechol-O-Methyltransferase

Q: What is the COMT gene?

COMT (Catechol-O-Methyltransferase) is located on chromosome 22q11.21. Degrades catecholamines (dopamine, epinephrine, norepinephrine) in the prefrontal cortex. The Val/Met polymorphism creates a spectrum of dopamine metabolism rates affecting cognition, pain, and stress response.

Chromosome 22q11.21

Degrades catecholamines (dopamine, epinephrine, norepinephrine) in the prefrontal cortex. The Val/Met polymorphism creates a spectrum of dopamine metabolism rates affecting cognition, pain, and stress response.

Pharmacogenomic Variants

rs4680Drug response / Risk factor

Val158Met — Pain sensitivity and psychiatric disorders

Peptide Therapeutic Approaches

COMT-stabilizing peptides for the Met allele, allosteric modulators for activity normalization, and genotype-informed analgesic peptide design.

Related Therapeutics

Entacapone (COMT inhibitor)Morphine (affected by COMT status)

Associated Conditions

Pain Sensitivity and Opioid Response (COMT/OPRM1)

Genetic variation in COMT (Val158Met) and OPRM1 (A118G) creates a wide spectrum of pain sensitivity and opioid analgesic requirements. Personalized pain management is one of the most promising applications of pharmacogenomics.

Analyze COMT variants with PepFold

Submit rs4680 and get ranked peptide candidates in under 2 minutes.

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