What pharmacogenomic variants are known in CYP2C9?

Key variants in CYP2C9: rs1799853 (CYP2C9*2 (Arg144Cys)), rs1057910 (CYP2C9*3 (Ile359Leu)). These variants are associated with Warfarin sensitivity, NSAID adverse effects, Sulfonylurea hypoglycemia.

Can PepFold design peptides targeting CYP2C9?

Yes. PepFold accepts rsIDs associated with CYP2C9, maps them to the protein structure, and generates peptide candidates. Genotype-independent anticoagulant peptides that bypass CYP2C9 metabolism entirely, targeting thrombin or Factor Xa directly.

Gene Database

CYP2C9 — Cytochrome P450 2C9

Q: What is the CYP2C9 gene?

CYP2C9 (Cytochrome P450 2C9) is located on chromosome 10q23.33. Metabolizes ~15% of clinical drugs including warfarin (S-enantiomer), NSAIDs, sulfonylureas, and losartan. CYP2C9 genotype is part of FDA warfarin dosing guidelines.

Chromosome 10q23.33

Metabolizes ~15% of clinical drugs including warfarin (S-enantiomer), NSAIDs, sulfonylureas, and losartan. CYP2C9 genotype is part of FDA warfarin dosing guidelines.

Pharmacogenomic Variants

rs1799853Drug response

CYP2C9*2 (Arg144Cys) — Warfarin sensitivity

rs1057910Drug response

CYP2C9*3 (Ile359Leu) — Warfarin sensitivity

Peptide Therapeutic Approaches

Genotype-independent anticoagulant peptides that bypass CYP2C9 metabolism entirely, targeting thrombin or Factor Xa directly.

Related Therapeutics

WarfarinIbuprofenCelecoxibGlipizideLosartan

Associated Conditions

Warfarin Sensitivity

Genetic variation in VKORC1 and CYP2C9 determines warfarin dose requirements. FDA recommends pharmacogenomic testing, and genotype-guided dosing reduces bleeding events by 30%. It is the most established pharmacogenomic application in clinical practice.

Drug Metabolism Disorders (CYP450 Pharmacogenomics)

Genetic variation in cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP2C9) creates a spectrum from ultra-rapid to poor metabolizers. This affects ~25% of all prescribed medications and is the foundation of clinical pharmacogenomics.

Analyze CYP2C9 variants with PepFold

Submit rs1799853, rs1057910 and get ranked peptide candidates in under 2 minutes.

Try Analysis View Pricing