What pharmacogenomic variants are known in CYP2D6?

Key variants in CYP2D6: rs3892097 (CYP2D6*4 (splicing defect)). These variants are associated with Poor drug metabolism, Ultra-rapid metabolism, Adverse drug reactions.

Gene Database

CYP2D6 — Cytochrome P450 2D6

Q: What is the CYP2D6 gene?

CYP2D6 (Cytochrome P450 2D6) is located on chromosome 22q13.2. Phase I drug metabolism enzyme responsible for ~25% of clinical drugs. Highly polymorphic with >100 known alleles ranging from gene deletion to ultra-rapid multiplication.

Q: Can PepFold design peptides targeting CYP2D6?

Yes. PepFold accepts rsIDs associated with CYP2D6, maps them to the protein structure, and generates peptide candidates. Enzyme-modulating peptides for activity normalization, allosteric regulators targeting CYP2D6 active site access channels, and metabolism-independent peptide drug designs.

Chromosome 22q13.2

Phase I drug metabolism enzyme responsible for ~25% of clinical drugs. Highly polymorphic with >100 known alleles ranging from gene deletion to ultra-rapid multiplication.

Pharmacogenomic Variants

rs3892097Drug response

CYP2D6*4 (splicing defect) — Poor drug metabolism

Peptide Therapeutic Approaches

Enzyme-modulating peptides for activity normalization, allosteric regulators targeting CYP2D6 active site access channels, and metabolism-independent peptide drug designs.

Related Therapeutics

CodeineTamoxifenFluoxetineMetoprolol

Associated Conditions

Drug Metabolism Disorders (CYP450 Pharmacogenomics)

Genetic variation in cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP2C9) creates a spectrum from ultra-rapid to poor metabolizers. This affects ~25% of all prescribed medications and is the foundation of clinical pharmacogenomics.

Analyze CYP2D6 variants with PepFold

Submit rs3892097, rs16947, rs1065852 and get ranked peptide candidates in under 2 minutes.

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