What pharmacogenomic variants are known in MC1R?

Key variants in MC1R: rs1805007 (Arg151Cys). These variants are associated with Melanoma risk, Anesthesia response variation, UV sensitivity.

Gene Database

MC1R — Melanocortin 1 Receptor

Q: What is the MC1R gene?

MC1R (Melanocortin 1 Receptor) is located on chromosome 16q24.3. Controls eumelanin vs pheomelanin synthesis ratio in melanocytes. Also affects pain perception, inflammation, and DNA repair capacity independent of pigmentation.

Q: Can PepFold design peptides targeting MC1R?

Yes. PepFold accepts rsIDs associated with MC1R, maps them to the protein structure, and generates peptide candidates. Alpha-MSH analog peptides for photoprotection, MC1R agonist peptides enhancing DNA repair in melanocytes, and genotype-specific melanocortin-targeting therapeutics.

Chromosome 16q24.3

Controls eumelanin vs pheomelanin synthesis ratio in melanocytes. Also affects pain perception, inflammation, and DNA repair capacity independent of pigmentation.

Pharmacogenomic Variants

rs1805007Risk factor / Drug response

Arg151Cys — Melanoma risk and anesthesia response

Peptide Therapeutic Approaches

Alpha-MSH analog peptides for photoprotection, MC1R agonist peptides enhancing DNA repair in melanocytes, and genotype-specific melanocortin-targeting therapeutics.

Related Therapeutics

Afamelanotide (Scenesse, MC1R agonist)Melanotan II (research)

Associated Conditions

Melanoma Genetic Risk (MC1R)

MC1R variants, particularly rs1805007 (Arg151Cys), increase melanoma risk 2-4 fold independent of UV exposure by impairing DNA repair in melanocytes. Also affects anesthesia requirements.

Analyze MC1R variants with PepFold

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