OPRM1 — Mu-Opioid Receptor 1
Chromosome 6q25.2
Primary receptor for endogenous opioid peptides (beta-endorphin, enkephalins) and opioid analgesics. Mediates analgesia, reward, respiratory depression, and physical dependence.
Pharmacogenomic Variants
Peptide Therapeutic Approaches
Genotype-optimized opioid peptide analogs with improved receptor selectivity, biased agonist peptides favoring analgesia over respiratory depression, and beta-endorphin mimetics.
Related Therapeutics
Associated Conditions
Genetic variation in COMT (Val158Met) and OPRM1 (A118G) creates a wide spectrum of pain sensitivity and opioid analgesic requirements. Personalized pain management is one of the most promising applications of pharmacogenomics.
Addiction Susceptibility (DRD2/OPRM1)Genetic variation in dopamine (DRD2/ANKK1) and opioid (OPRM1) receptor systems creates differential vulnerability to substance use disorders. Personalized pharmacotherapy guided by genotype is an emerging paradigm.
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