What pharmacogenomic variants are known in VKORC1?

Key variants in VKORC1: rs9923231 (-1639G>A (promoter)). These variants are associated with Warfarin sensitivity, Vitamin K-dependent coagulation disorders.

Can PepFold design peptides targeting VKORC1?

Yes. PepFold accepts rsIDs associated with VKORC1, maps them to the protein structure, and generates peptide candidates. Selective VKORC1 inhibitor peptides with better therapeutic windows than warfarin, and vitamin K cycle modulator peptides for fine-tuned anticoagulation.

Gene Database

VKORC1 — Vitamin K Epoxide Reductase Complex Subunit 1

Q: What is the VKORC1 gene?

VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is located on chromosome 16p11.2. Direct pharmacological target of warfarin. Recycles vitamin K, essential for gamma-carboxylation of clotting factors II, VII, IX, and X.

Chromosome 16p11.2

Direct pharmacological target of warfarin. Recycles vitamin K, essential for gamma-carboxylation of clotting factors II, VII, IX, and X.

Pharmacogenomic Variants

rs9923231Drug response

-1639G>A (promoter) — Warfarin sensitivity

Peptide Therapeutic Approaches

Selective VKORC1 inhibitor peptides with better therapeutic windows than warfarin, and vitamin K cycle modulator peptides for fine-tuned anticoagulation.

Related Therapeutics

WarfarinAcenocoumarolPhenprocoumon

Associated Conditions

Warfarin Sensitivity

Genetic variation in VKORC1 and CYP2C9 determines warfarin dose requirements. FDA recommends pharmacogenomic testing, and genotype-guided dosing reduces bleeding events by 30%. It is the most established pharmacogenomic application in clinical practice.

Analyze VKORC1 variants with PepFold

Submit rs9923231, rs9934438 and get ranked peptide candidates in under 2 minutes.

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