Can PepFold design peptides for rs1799971?

Yes. PepFold accepts rs1799971 as input, annotates it via ClinVar, maps it to the OPRM1 protein via UniProt, generates peptide candidates targeting affected functional domains, predicts their 3D structures with ESMFold, and produces a scored report with Fmoc-SPPS synthesis protocols.

SNP Database

rs1799971 — OPRM1 A118G (Asn40Asp)

Q: What gene is rs1799971 in?

rs1799971 is a variant in the OPRM1 (Mu-Opioid Receptor 1) gene located on chromosome 6q25.2. Primary receptor for endogenous opioid peptides (beta-endorphin, enkephalins) and opioid analgesics. Mediates analgesia, reward, respiratory depression, and physical dependence.

Q: What is the clinical significance of rs1799971?

rs1799971 is classified as "Drug response" in ClinVar. The Asn40Asp substitution removes an N-glycosylation site in the extracellular domain of the mu-opioid receptor. This alters receptor trafficking, surface expression, and downstream signaling. Carriers often require higher morphine doses for equivalent analgesia.

Drug response · ~15% Caucasians, ~50% East Asians

rs1799971 in the mu-opioid receptor affects opioid binding affinity and analgesic response. The Asp40 variant increases beta-endorphin binding 3-fold but may reduce receptor expression, altering pain perception and opioid drug requirements.

Molecular Mechanism

The Asn40Asp substitution removes an N-glycosylation site in the extracellular domain of the mu-opioid receptor. This alters receptor trafficking, surface expression, and downstream signaling. Carriers often require higher morphine doses for equivalent analgesia.

Peptide Therapeutic Relevance

Opioid peptide analogs with genotype-optimized receptor binding are an active research area. PepFold generates candidates considering the Asn40Asp mutation to design receptor-specific analgesic peptides.

Gene: OPRM1 (Mu-Opioid Receptor 1)

Primary receptor for endogenous opioid peptides (beta-endorphin, enkephalins) and opioid analgesics. Mediates analgesia, reward, respiratory depression, and physical dependence.

Chromosome 6q25.2

Full OPRM1 gene profile →

Condition: Pain Sensitivity and Opioid Response (COMT/OPRM1)

Genetic variation in COMT (Val158Met) and OPRM1 (A118G) creates a wide spectrum of pain sensitivity and opioid analgesic requirements. Personalized pain management is one of the most promising applications of pharmacogenomics.

Prevalence: Up to 40% variance in opioid requirements is genetically determined

Full Pain Sensitivity and Opioid Response (COMT/OPRM1) profile →

Analyze rs1799971 with PepFold

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