What gene is rs1800497 in?

rs1800497 is a variant in the ANKK1/DRD2 (ANKK1/DRD2) gene.

Can PepFold design peptides for rs1800497?

Yes. PepFold accepts rs1800497 as input, annotates it via ClinVar, maps it to the ANKK1/DRD2 protein via UniProt, generates peptide candidates targeting affected functional domains, predicts their 3D structures with ESMFold, and produces a scored report with Fmoc-SPPS synthesis protocols.

SNP Database

rs1800497 — ANKK1/DRD2 Taq1A (Glu713Lys)

Q: What is the clinical significance of rs1800497?

rs1800497 is classified as "Risk factor" in ClinVar. The variant is in the ANKK1 gene, ~10 kb downstream of DRD2, but affects DRD2 expression through regulatory mechanisms. Reduced D2 receptor availability creates a 'reward deficiency syndrome' where individuals seek more intense stimulation to achieve normal dopamine signaling.

Risk factor · ~20% global (A1 allele)

rs1800497 (Taq1A) is near the DRD2 dopamine receptor gene and reduces D2 receptor density in the striatum by 30-40%. It is associated with increased risk of substance use disorders, reward-seeking behavior, and obesity.

Molecular Mechanism

The variant is in the ANKK1 gene, ~10 kb downstream of DRD2, but affects DRD2 expression through regulatory mechanisms. Reduced D2 receptor availability creates a 'reward deficiency syndrome' where individuals seek more intense stimulation to achieve normal dopamine signaling.

Peptide Therapeutic Relevance

DRD2-modulating peptides and dopamine system-targeting neuropeptides are emerging therapeutic approaches for addiction. PepFold generates candidates exploring D2 receptor positive allosteric modulation.

Condition: Addiction Susceptibility (DRD2/OPRM1)

Genetic variation in dopamine (DRD2/ANKK1) and opioid (OPRM1) receptor systems creates differential vulnerability to substance use disorders. Personalized pharmacotherapy guided by genotype is an emerging paradigm.

Prevalence: ~35 million people worldwide with substance use disorders (UNODC 2023)

Full Addiction Susceptibility (DRD2/OPRM1) profile →

Analyze rs1800497 with PepFold

Submit rs1800497 and get ranked peptide candidates with 3D structures and synthesis protocols in under 2 minutes.

Try Analysis View Pricing